Professor of Organic Chemistry
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Research Interests
Synthetic Organic and Medicinal Chemistry [main]
- Discovery and development of small organic molecules and of natural product analogues/ derivatives (e.g. abietanes; polyamines; endoperoxides; retinoids; psoralens) with anticancer (Hedgehod pathway inhibitors; Cancer Stem Cell differentiators; Anti-angiogenic agents), antibacterial (against MRSA strains) and antimalarial activity.
- Synthesis of Multitarget Inhibitors and of Hybrids or Bioconjugates aiming at improvement of the pharmacological profile of a bioactive compound
Mass Spectrometry [secondary]
- Synthesis of labeling reagents (heavy/ light) for applications in analysis by Mass Spectrometry.
- Solid Phase Synthesis of “chemical probes” for applications in Mass Spectrometry Proteomics.
Education
Ph.D. in Chemistry, Department of Chemistry, University of Patras, Greece
Diploma in Chemistry, Department of Chemistry, University of Patras, Greece
Professional training and academic appointments
2021-today : Professor of Organic Chemistry, Department of Chemistry, University of Patras,
2016-2021 : Associate Professor of Organic Chemistry, Department of Chemistry, University of Patras,
-2017 (September 11th to October 10th) : Visiting Professor at Universitè Paul Sabatier, Toulouse, France
2010-2016: Assistant Professor of Organic Chemistry, Department of Chemistry, University of Patras,
-2009 : Post Doctoral Fellow (The research Council of Norway) at University of Bergen, Bergen, Norway
2006- 2010: Lecturer in Organic Chemistry, Department of Chemistry, University of Patras,
2005- 2006 : Post Doctoral Fellow (Greek Scholarship Foundation), Laboratory of Organic Chemistry, Department of Chemistry, University of Patras, Greece,
2005: Part-time Lecturer, Department of Pharmacy, University of Patras,
2003- 2005: Post Doctoral Researcher, Department of Chemistry, University of Patras, Greece,
1995- 1996 : Research Fellow (EU fellowship, HCM), Department of Chemistry, University of Calabria, Cosenza, Italy,
1994: Research Fellow (EU fellowship, HCM), Department of Chemistry, University of Minho, Braga, Portugal.
Professional Societies American Chemical Society, Royal Society of Chemistry, American Society for Mass Spectrometry, Association of Greek Chemists | @@@@@@ |
Proposal Evaluator for REPRISE/ CINECA, Ministero dell'Istruzione dell'Università e della Ricerca, ITALY Kingdom of Saudi Arabia, Ministry of Education, SAUDI ARABIA General Secretariat for Research and Technology (GSRT), GREECE
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Invited Lectures
September 2023: 5th Symposium – Chemistry at the Interface of Biology and Medicine, Chania, Crete, Greece, Title: “Synthesis of Novel Artemisinin Hybrids with Potent Antimalarial Activity”.
April 2023: Universidad Catòlica de Cordoba, Cordoba, Argentina, Title: "Artemisinin: Nature’s gift to the arsenal against malaria and cancer”
March 2023: Lusofona University of Lisbon, Lisbon, Portugal, Title: "Targeting drug resistance in cancer stem cells: Hedgehog pathway inhibitors”
November 2019: Universidad de Biobio, Chillan, Chile, [a] Title: "Artemisinin: Nature’s gift to the arsenal against malaria and cancer”, [b] Title: "Targeting drug resistance in cancer stem cells: Hedgehog pathway inhibitors".
September 2022: 4th Symposium – Chemistry at the Interface of Biology and Medicine, Patras, Greece, Title: “Liquid Phase Fragment Synthesis of New Analogs of Polyamine Toxins from Spiders and Wasps and Evaluation of their Antiproliferative Activity”.
September 2022: University of Lisbon, Faculty of Pharmacy, Lisbon, Portugal, Title: "Artemisinin: Nature’s gift to the arsenal against malaria and cancer”s. An interesting approach for the improvement of activity".
October 2020: AAFE 2020 – Primer Congreso Virtual FCQ- Universidad Católica de Córdoba, Argentina, Title: “Synthesis of Novel Artemisinin Hybrids and Conjugates with Potent Antimalarial Activity”
November 2019: Universidad de Biobio, Chillan, Chile, Title: "Synthetic methodologies towards orthogonally protected naturally occurring polyamines and their conjugation to bioactive molecules. An interesting approach for the improvement of activity". http://noticias.ubiobio.cl/2019/11/29/workshop-de-quimica-de-productos-naturales-y-sus-aplicaciones-en-la-ubb/
July 2018: Sapienza Università di Roma, Rome, Italy, [a] Title: "Artemisinin: Nature's gift to the arsenal against malaria and cancer". [b] Title: "Conjugation of polyamines to bioactive molecules. An interesting approach towards the improvement of their biological profile".
November 2017: Universidad Catòlica de Cordoba, Cordoba, Argentina, [a] Title: "Targeting drug resistance in cancer stem cells. Hedgehog pathway inhibitors- Taepeenin D" [b] Title: "Abietane diterpenes – high value natural precursors for the development of new antimicrobial agents".
September 2015: Universitè Paul Sabatier, Toulouse, France, Title: "Polyamine Bioconjugates".
February 2013: IPATIMUP- University of Porto, Porto, Portugal (COST ACTION CM1106), Title: “Total Synthesis of Acidic Retinoids: A Library of Potential Cancer Stem Cell Regulators”.
January 2012: University of Insubria, Varese, Italy, Title: “Mass Spectrometry techniques and applications on the analysis of biomolecules”.
November 2008: Kjemisk Institutt, University of Bergen, Bergen, Norway, Title: “Synthetic Studies Towards the Development of acidic retinoids and acid retinoid-psoralen conjugates and hybrids”.
October 2008: Workshop in the framework of international school of Doctorate “Bernadino Telesio School of Hard Sciences” University of Calabria, Cozenza, Italy, Title: “Synthetic Studies towards the Development of Acidic Retinoids and Acidic Retinoid-Psoralen Conjugates and Hybrids, Suitable for Structure-Activity Relationship Studies”.
September 2007: XXXI Convegno Nazionale della Diviosione di Chimica Organica della Societa Chimica Italiana (ATTI) University of Calabria, Cozenza, Italy, Title: “Synthetic Studies towards the Development of a Glutathione-based anticancer or antiviral drug delivery system”.
June 2007: ECTNA, Newly Appointed Academic Teaching Staff Residential Summer School, Sliema, Malta, Title:“Survival for new Lecturers”.
Scholarships
2009: Scholarship from The Research Council of Norway for postdoctoral research in the University of Bergen, Norway.
2005-2006: Scholarship from Greek State Scholarships’ Foundation for postdoctoral research in Greece.
1994, 1995- 1996: Human Capital and Mobility Fellowship for research in the Universities of Braga and Calabria, respectively.
International Schools
October 2007: MAOS 2007 Microwave Assisted Organic Synthesis, San Francisco, CA, USA.
September 2004: Ischia Advanced School of Organic Chemistry (IASOC 2004), Ischia, ITALY.
June 1993 & July 1996: NATO Advanced Study Institute (ASI) on Mass Spectrometry in the Biomolecular Science, (NATO scholarship) in Lacco Ameno, Ischia and Altavilla Milicia, Palermo, ITALY respectively.
Teaching Activities
Undergraduate Courses: Synthetic Organic Chemistry (FGI), Special Topics of Organic Chemistry (Mass Spectrometry), Organic Chemistry of Functional Groups II, Experimental Organic Chemistry (I and II lab courses), Organic Chemistry Lab-course (Dept. of Biology).
Postgraduate Courses: Organic Synthesis of Drugs, Advanced Synthetic Organic Chemistry (FGI), Techniques for Purification and Identification/ Characterization of Synthetic Products (Mass Spectrometry Proteomics).
Publications
International Scientific Journals with Peer Review System:62
International Scientific Books: 1
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